Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663N Zhongshan Road, Shanghai 200062, China.
Org Biomol Chem. 2013 Nov 21;11(43):7550-8. doi: 10.1039/c3ob41693c.
Ophiobolin and variecolin type sesterterpenoids belong to cyclooctane-containing natural products. Both sesterterpenoids have challenging structures and appealing biological activities. We envisioned that a key tandem ring closing metathesis of dienynes could provide the basic skeleton of ophiobolin A and variecolin. We report herein the detailed reactivities of the dienynes which furnished the 5-8-5 and 5-8-6-5 rings efficiently.
蛇孢菌素和瓦列醇型倍半萜属于含环辛烷的天然产物。这两种倍半萜都具有具有挑战性的结构和吸引人的生物活性。我们设想，二炔的关键串联环 closing metathesis 可以提供蛇孢菌素 A 和瓦列醇的基本骨架。我们在此报告了二炔的详细反应性，这些反应性可以有效地提供 5-8-5 和 5-8-6-5 环。
