Wang C, Zhang C, Liu R L, Song X L
Thorac Cardiovasc Surg. 1985 Apr;33(2):94-7.
In 47 animals (rats, rabbits) the cardiac side effects of prolonged (3 to 6 hours) abdominal aortic cross-clamping and unclamping (3 to 6 hours) were investigated. The relative instantaneous ventricular vascular volume (IVVV), a factor reflecting myocardial blood supply and the rate pressure product (RPP) representing myocardial oxygen demand were used as parameters. Following cross-clamping the IVVV showed an initial decrease while the myocardial oxygen demand revealed a sudden increase. After unclamping, the myocardial oxygen demand decreased and IVVV improved. Minimal levels of both IVVV and RPP occurred at 6 hours following unclamping. This may be an effect of a myocardial inhibiting substance, released by ischemia and necrosis of the lower extremity.
在47只动物（大鼠、兔子）中，研究了延长（3至6小时）腹主动脉夹闭和松开（3至6小时）的心脏副作用。使用反映心肌血液供应的相对瞬时心室血管容积（IVVV）和代表心肌需氧量的速率压力乘积（RPP）作为参数。夹闭后，IVVV最初下降，而心肌需氧量突然增加。松开后，心肌需氧量下降，IVVV改善。IVVV和RPP的最低水平出现在松开后6小时。这可能是下肢缺血和坏死释放的心肌抑制物质的作用。
