C5和C7分子内氢键稳定了N-吡嗪甲酰基-加巴喷丁（Pyr-Gpn-OH）的结构。
C5 and C7 intramolecular hydrogen bonds stabilize the structure of N-pyrazinoyl-gabapentin (Pyr-Gpn-OH).
作者信息
Wani Naiem Ahmad, Gupta Vivek Kumar, Kant Rajni, Aravinda Subrayashastry, Rai Rajkishor
机构信息
Medicinal Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi 180 001, India.
出版信息
Acta Crystallogr C. 2013 Oct;69(Pt 10):1170-2. doi: 10.1107/S0108270113021781. Epub 2013 Sep 6.
2-{1-[(Pyrazin-2-ylformamido)methyl]cyclohexyl}acetic acid (Pyr-Gpn-OH), C14H19N3O3, is an N-protected derivative of gabapentin (Gpn). The compound crystallizes in the triclinic space group P1 and the molecular conformation is stabilized by intramolecular five- (C5) and seven-membered (C7) hydrogen-bonded rings. The packing of the molecules reveals intermolecular O-H···O and C-H···N hydrogen bonds, together with π-π interactions.
2-{1-[(吡嗪-2-基甲酰胺基)甲基]环己基}乙酸（Pyr-Gpn-OH），C₁₄H₁₉N₃O₃，是加巴喷丁（Gpn）的一种N-保护衍生物。该化合物在三斜晶系空间群P1中结晶，分子构象通过分子内五元（C5）和七元（C7）氢键环得以稳定。分子堆积显示出分子间O-H···O和C-H···N氢键以及π-π相互作用。
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