Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
J Mol Endocrinol. 2013 Nov 26;51(3):T115-40. doi: 10.1530/JME-13-0212. Print 2013 Dec.
The nuclear receptor superfamily includes many receptors, identified based on their similarity to steroid hormone receptors but without a known ligand. The study of how these receptors are diversely regulated to interact with genomic regions to control a plethora of biological processes has provided critical insight into development, physiology, and the molecular pathology of disease. Here we provide a compendium of these so-called orphan receptors and focus on what has been learned about their modes of action, physiological functions, and therapeutic promise.
核受体超家族包括许多受体，它们是根据与甾体激素受体的相似性来识别的，但没有已知的配体。研究这些受体如何多样化调节以与基因组区域相互作用，从而控制众多生物学过程，为我们提供了对发育、生理学和疾病的分子病理学的重要见解。在这里，我们提供了这些所谓的孤儿受体的概要，并重点介绍了关于它们的作用模式、生理功能和治疗前景的知识。
