Andersen Louise K, Lehman Julia S, Davis Mark D P
Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Acta Derm Venereol. 2014 May;94(3):298-302. doi: 10.2340/00015555-1652.
Calciphylaxis causes calcification, thrombosis, cutaneous ischemia, and necrosis in the skin and subcutaneous tissue. It is unclear to what extent it involves other organs. To identify whether other organs are affected we reviewed pathology reports of patients with calciphylaxis who underwent autopsy at Mayo Clinic, Rochester, Minnesota, between January 1, 1970, and December 31, 2011. Three patients were identified: two patients had a diagnosis of end-stage renal disease secondary to diabetes mellitus before the diagnosis of calciphylaxis; the third patient had calciphylaxis associated with metastatic cholangiocarcinoma without end-stage renal disease. Autopsy reports showed that despite evidence of vessel calcification elsewhere, there was no evidence of calciphylaxis in other organs. All patients had histopathologic evidence of cardiovascular calcification, and atherosclerosis of coronary arteries and aorta. Calcification of pancreatic vessels and renal vessels was also noted. In this study population, calciphylaxis was a cutaneous process alone.
钙过敏症会导致皮肤和皮下组织出现钙化、血栓形成、皮肤缺血和坏死。目前尚不清楚它累及其他器官的程度如何。为了确定其他器官是否受到影响，我们回顾了1970年1月1日至2011年12月31日期间在明尼苏达州罗切斯特市梅奥诊所接受尸检的钙过敏症患者的病理报告。共识别出3例患者：2例患者在被诊断为钙过敏症之前已被诊断为糖尿病继发的终末期肾病；第3例患者的钙过敏症与转移性胆管癌相关，无终末期肾病。尸检报告显示，尽管在其他部位有血管钙化的证据，但在其他器官中没有钙过敏症的证据。所有患者均有心血管钙化以及冠状动脉和主动脉粥样硬化的组织病理学证据。还注意到胰腺血管和肾血管的钙化。在该研究人群中，钙过敏症仅是一种皮肤病变。
