Institute of Nutrition and Food Technology (INTA), University of Chile, Av. El Líbano 5524, Macul, Santiago, Chile.
Biol Trace Elem Res. 2013 Dec;156(1-3):1-4. doi: 10.1007/s12011-013-9823-4. Epub 2013 Oct 6.
Copper (Cu) deficiency has been reported to influence lipid metabolism, but the effects in humans are controversial. To evaluate the effects of 8 mg Cu/day supplementation (as copper sulfate) for 6 months on the lipid profile and hepatic function of apparently healthy men. The design was randomized double-blind placebo-controlled clinical trial.
60 apparently healthy males aged 18-51 years were randomly assigned to Cu supplementation (n = 30) or placebo (n = 30). There was a nonsignificant reduction of 17 % in total cholesterol in both groups after supplementation. A 23 % nonsignificant reduction was observed in LDL cholesterol levels in the supplemented group. There was a nonsignificant increase of HDL cholesterol of 47 and 66 % in the control and supplemented groups, respectively. Triglyceride levels over 150 mg/dl were found in 17 subjects supplemented and 13 controls at baseline and decreased after supplementation to seven and eight subjects, respectively. There were no effects on serum Cu concentration or ceruloplasmin (protein) and hepatic transaminases. Supplementation of 8 mg Cu for 6 months had no effect on lipid profile of apparently healthy Chilean men with adequate Cu status.
铜（Cu）缺乏已被报道会影响脂质代谢，但人体的影响仍存在争议。本研究旨在评估每天补充 8 毫克 Cu（以硫酸铜形式）6 个月对健康男性的血脂谱和肝功能的影响。方法：采用随机、双盲、安慰剂对照的临床试验设计。60 名年龄在 18-51 岁的健康男性被随机分配至 Cu 补充组（n = 30）或安慰剂组（n = 30）。补充后两组的总胆固醇均有 17%的非显著性降低。补充组 LDL 胆固醇水平降低了 23%，但无统计学意义。对照组和补充组的 HDL 胆固醇分别增加了 47%和 66%，但无统计学意义。17 名补充组和 13 名对照组的甘油三酯水平在 150mg/dl 以上，补充后分别降至 7 名和 8 名。血清 Cu 浓度或铜蓝蛋白（蛋白）和肝转氨酶无变化。结论：对于智利 Cu 状态充足的健康男性，补充 8 毫克 Cu 6 个月对血脂谱没有影响。
