Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, Jiangsu, People's Republic of China.
Biol Trace Elem Res. 2021 Aug;199(8):2851-2857. doi: 10.1007/s12011-020-02423-1. Epub 2020 Oct 8.
Studies have evaluated the effect of copper (Cu) supplementation on blood lipid level. We therefore investigated whether the supplement of Cu on blood lipid level will have an impact in a meta-analysis on randomized controlled trials (RCTs). Literature search was conducted in Scopus, PubMed, Web of Science, and Cochrane Library (from database to January 2020). Randomized controlled trials of Cu supplementation on blood lipid level were retrieved according to the requirements of systematic review, and the quality of the included research was evaluated. Then the meta-analysis was performed. Data from 5 trials representing 176 participants were examined. Pooled mean net change in total cholesterol (TC) (standard mean difference(SMD) [95% CI] = - 0.05 [- 0.52, 0.43]), low density lipoprotein cholesterol (LDL-C) (SMD [95% CI] = 0.22 [- 0.46, 0.89]), and high density lipoprotein cholesterol (HDL-C) (SMD [95% CI] = 0.18 [- 0.14, 0.49]) for those treated with Cu supplementation had no significant difference when compared with control. Cu supplementation has not affected blood lipids in the result of meta-analysis. More research is needed to determine if this pattern will apply broadly.
研究已经评估了铜（Cu）补充对血脂水平的影响。因此，我们通过对随机对照试验（RCT）的荟萃分析来调查 Cu 对血脂水平的补充是否会产生影响。根据系统评价的要求，在 Scopus、PubMed、Web of Science 和 Cochrane Library 中进行了文献检索，并检索了关于 Cu 补充对血脂水平影响的 RCT，评估了纳入研究的质量。然后进行了荟萃分析。共纳入 5 项试验，涉及 176 名参与者，评估了总胆固醇（TC）（标准化均数差（SMD）[95%CI] = -0.05 [-0.52, 0.43]）、低密度脂蛋白胆固醇（LDL-C）（SMD [95%CI] = 0.22 [-0.46, 0.89]）和高密度脂蛋白胆固醇（HDL-C）（SMD [95%CI] = 0.18 [-0.14, 0.49]）的综合变化。与对照组相比，Cu 补充组的变化无显著差异。荟萃分析结果表明，Cu 补充并未影响血脂。需要更多的研究来确定这种模式是否具有普遍性。
