Boff Diego F, Goldani Luciano Z
MD, Infectious Disease Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90640-000, Brazil.
Trop Doct. 2013 Oct;43(4):148-50. doi: 10.1177/0049475513502961. Epub 2013 Oct 4.
There is a need for intravenous therapy for severe forms of tuberculosis in those who are HIV-positive, diabetic, have cystic fibrosis, extensive gastrointestinal involvement, haemodynamic instability with difficulty to take and absorb oral medications, which results in a lack of appropriate therapeutic effect during treatment, such as not creating the optimal blood concentration of the substance. We report an HIV-infected patient presenting with severe disseminated tuberculosis with extensive intestinal involvement which was successfully treated with an initial combination regimen of injectable and oral anti-tuberculosis agents. We discuss and emphasize the importance of an initial regimen with injectable and oral agents for treating severe forms of tuberculosis.
对于HIV阳性、糖尿病、患有囊性纤维化、有广泛胃肠道受累、存在血流动力学不稳定且难以服用和吸收口服药物的重症结核病患者，需要进行静脉治疗，因为口服药物会导致治疗期间缺乏适当的治疗效果，例如无法达到药物的最佳血药浓度。我们报告了一名HIV感染患者，该患者患有严重播散性结核病并伴有广泛肠道受累，通过初始联合使用注射用和口服抗结核药物的方案成功治愈。我们讨论并强调了使用注射用和口服药物的初始方案治疗重症结核病的重要性。
