Rodríguez-Lara Vianey, Morales-Rivero Alonso, Rivera-Cambas Angelica Muñiz, Fortoul Teresa I
Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, México
Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, México.
Toxicol Ind Health. 2016 Feb;32(2):367-74. doi: 10.1177/0748233713501364. Epub 2013 Oct 4.
Infertility is becoming a health problem, which has increased mainly in megacities, and several studies have shown its association with environmental pollution. Air pollution has been linked to alterations in sperm parameters, both in humans and animal models. In male humans, it has been associated with reduced semen quality and DNA alterations. Vanadium is a transition element that has increased in recent decades as a component of air suspended matter and has been associated with reprotoxic effects in animal models. Few are the mechanisms described by which the vanadium produces these effects, and cytoskeleton interaction is a possibility. We reported immunohistochemical changes in actin testicular cytoskeleton in a vanadium inhalation experimental mice model. Our findings show that exposure to vanadium pentoxide (0.02 M) results in actin decrease in testicular cells from 3-12 weeks exposure time; this effect was statistically significant and exposure time dependent. Actin cytoskeleton damage is a mechanism that could explain vanadium reprotoxic effects and its association with impaired fertility.
不孕不育正成为一个健康问题，主要在大城市中有所增加，并且多项研究已表明其与环境污染有关。空气污染已被证明与人类和动物模型的精子参数改变有关。在男性人类中，它与精液质量下降和DNA改变有关。钒是一种过渡元素，近几十年来作为空气悬浮物的一种成分含量有所增加，并且在动物模型中已被证明具有生殖毒性作用。钒产生这些影响的机制鲜有报道，与细胞骨架相互作用是一种可能。我们报道了在钒吸入实验小鼠模型中睾丸肌动蛋白细胞骨架的免疫组化变化。我们的研究结果表明，暴露于五氧化二钒（0.02 M）会导致在3至12周的暴露时间内睾丸细胞中的肌动蛋白减少；这种影响具有统计学意义且与暴露时间相关。肌动蛋白细胞骨架损伤是一种可以解释钒的生殖毒性作用及其与生育能力受损之间关联的机制。
