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纳米材料注册中心:促进多元化纳米材料社区的数据共享和分析。

The Nanomaterial Registry: facilitating the sharing and analysis of data in the diverse nanomaterial community.

机构信息

RTI International, Durham, NC, USA.

出版信息

Int J Nanomedicine. 2013;8 Suppl 1(Suppl 1):7-13. doi: 10.2147/IJN.S40722. Epub 2013 Sep 16.

Abstract

The amount of data being generated in the nanotechnology research space is significant, and the coordination, sharing, and downstream analysis of the data is complex and consistently deliberated. The complexities of the data are due in large part to the inherently complicated characteristics of nanomaterials. Also, testing protocols and assays used for nanomaterials are diverse and lacking standardization. The Nanomaterial Registry has been developed to address such challenges as the need for standard methods, data formatting, and controlled vocabularies for data sharing. The Registry is an authoritative, web-based tool whose purpose is to simplify the community's level of effort in assessing nanomaterial data from environmental and biological interaction studies. Because the Registry is meant to be an authoritative resource, all data-driven content is systematically archived and reviewed by subject-matter experts. To support and advance nanomaterial research, a set of minimal information about nanomaterials (MIAN) has been developed and is foundational to the Registry data model. The MIAN has been used to create evaluation and similarity criteria for nanomaterials that are curated into the Registry. The Registry is a publicly available resource that is being built through collaborations with many stakeholder groups in the nanotechnology community, including industry, regulatory, government, and academia. Features of the Registry website (http://www.nanomaterialregistry.org) currently include search, browse, side-by-side comparison of nanomaterials, compliance ratings based on the quality and quantity of data, and the ability to search for similar nanomaterials within the Registry. This paper is a modification and extension of a proceedings paper for the Institute of Electrical and Electronics Engineers.

摘要

在纳米技术研究领域产生的数据量非常庞大,因此协调、共享和对这些数据进行下游分析非常复杂,需要反复斟酌。数据的复杂性在很大程度上是由于纳米材料固有的复杂特性造成的。此外,用于纳米材料的测试协议和检测方法多种多样,缺乏标准化。为了解决这些挑战,例如需要标准方法、数据格式和数据共享的受控词汇,开发了纳米材料注册中心。该注册中心是一个权威的基于网络的工具,旨在简化社区在评估环境和生物相互作用研究中纳米材料数据方面的工作难度。由于注册中心旨在成为一个权威的资源,因此所有基于数据的内容都由主题专家进行系统存档和审查。为了支持和推进纳米材料研究,开发了一套关于纳米材料的最小信息 (MIAN),并作为注册中心数据模型的基础。MIAN 已用于创建对注册中心中经过策展的纳米材料进行评估和相似性标准。该注册中心是一个公开的资源,正在通过与纳米技术领域的许多利益相关者群体(包括工业界、监管机构、政府和学术界)合作进行构建。该注册中心网站(http://www.nanomaterialregistry.org)的功能目前包括搜索、浏览、纳米材料并排比较、基于数据质量和数量的合规评级以及在注册中心内搜索相似纳米材料的功能。本文是为电气和电子工程师协会的会议论文集修改和扩展的版本。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62b6/3790275/9700e76000cb/ijn-8-007Fig1.jpg

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