Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa.
Mol Cancer. 2013 Oct 7;12(1):117. doi: 10.1186/1476-4598-12-117.
The T-box transcription factor, TBX3, is overexpressed in several cancers and has been proposed as a chemotherapeutic target. Several lines of evidence suggest that TBX3 may be a key contributor to malignant melanoma, a highly aggressive and intractable disease. Using in vitro and in vivo assays we demonstrate here for the first time that overexpressing TBX3 in non-tumourigenic early stage melanoma cells is sufficient to promote tumour formation and invasion. Furthermore, we show that TBX3 may play an important role as a reciprocal switch between substrate dependent cell proliferation and tumour invasion.
T 盒转录因子 TBX3 在多种癌症中过表达，并被提议作为一种化疗靶点。有几条证据表明，TBX3 可能是恶性黑色素瘤的一个关键贡献者，恶性黑色素瘤是一种高度侵袭性和难治性疾病。在这里，我们首次通过体外和体内检测证明，在非肿瘤发生的早期黑色素瘤细胞中过表达 TBX3 足以促进肿瘤的形成和侵袭。此外，我们还表明，TBX3 可能在底物依赖性细胞增殖和肿瘤侵袭之间作为一个相互转换的开关发挥重要作用。
