药物性肝损伤的机制。
Mechanisms of drug-induced liver injury.
机构信息
USC Research Center for Liver Disease, Department of Medicine, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue (HMR101), Los Angeles, CA 90033, USA.
出版信息
Clin Liver Dis. 2013 Nov;17(4):507-18, vii. doi: 10.1016/j.cld.2013.07.002. Epub 2013 Aug 1.
Abstract
Drug-induced liver injury (DILI) represents a broad spectrum of liver manifestations. However, the most common manifestation is hepatocyte death following drug intake. DILI can be predictable and dose dependent with a notable example of acetaminophen toxicity. Idiosyncratic DILI occurs in an unpredictable fashion at low frequencies, implying that environmental and genetic factors alter the susceptibility of individuals to the insult (drugs).
摘要
药物性肝损伤（DILI）表现为广泛的肝脏病变谱。然而，最常见的表现是药物摄入后肝细胞死亡。DILI 可能是可预测的和剂量依赖性的，对乙酰氨基酚毒性就是一个显著的例子。特发性 DILI 以不可预测的低频率发生，这意味着环境和遗传因素改变了个体对损伤（药物）的易感性。
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