Zhao Shanshan, Zhang Lan, Zhao Junzhe, Tasnim Farah, Yu Hanry
Department of Pharmacy, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing Engineering Research Center for Nerve System Drugs, Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China.
Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore 117593, Singapore.
ILIVER. 2023 Nov 28;3(1):100075. doi: 10.1016/j.iliver.2023.11.002. eCollection 2024 Mar.
Through visual analysis of related literature, the main research direction and hot spots of liver sinusoidal endothelial cells (LSECs) in recent 24 years were explored.
This study used bibliometric analysis with CiteSpace, VOSviewer, Biblioshiny and online analytic tool bibliometric.com to provide a quantitative analysis, hot spot mining, and commentary of articles published in the field of LSECs research. The relevant literature in the Web of Science Core Collection (WOSCC) was searched from 2000 to 2023. The publications with topics or titles or keywords containing LSECs were included into this study. The countries, organizations, journals, authors, and keywords of the publications were summarized and analyzed.
This study included 3,747 publications from 14,132 authors belonging to 389 institutions in 61 countries/regions and published in 150 journals, with 156,309 citations. The United States contributed most (1,150) to the publications. The most productive institution was the University of Sydney. accounts for the most output (293, 7.8%), European authors had a widespread cooperation. The most productive author was Adam DH with 68 papers. Immunological function of LSECs is research hot spot.
This study highlights key trends based on a large dataset of the most influential publications about LSECs research over a 24-year period. It provides important clues and ideas for researchers focusing in this area and facilitates future liver disease mechanism, understanding, and treatment.
通过对相关文献的可视化分析，探索近24年肝窦内皮细胞（LSECs）的主要研究方向和热点。
本研究使用CiteSpace、VOSviewer、Biblioshiny和在线分析工具bibliometric.com进行文献计量分析，以对LSECs研究领域发表的文章进行定量分析、热点挖掘和评论。检索了2000年至2023年Web of Science核心合集（WOSCC）中的相关文献。纳入主题、标题或关键词中包含LSECs的出版物。对这些出版物的国家、机构、期刊、作者和关键词进行了总结和分析。
本研究纳入了来自61个国家/地区389个机构的14132名作者发表在150种期刊上的3747篇出版物，被引次数达156309次。美国对出版物的贡献最大（1150篇）。产出最多的机构是悉尼大学。 产出占比最高（293篇，7.8%），欧洲作者合作广泛。产出最多的作者是Adam DH，有68篇论文。LSECs的免疫功能是研究热点。
本研究基于24年期间关于LSECs研究的最具影响力出版物的大型数据集突出了关键趋势。它为专注于该领域的研究人员提供了重要线索和思路，并有助于未来对肝病机制的理解和治疗。
