Department of Pathology, VA Connecticut Health System and Yale University School of Medicine, 310 Cedar Street, LH 108, New Haven, CT 06516, USA.
Clin Liver Dis. 2013 Nov;17(4):547-64, vii-viii. doi: 10.1016/j.cld.2013.07.004. Epub 2013 Sep 4.
Drug-induced hepatotoxicity is underrecognized but increasingly identified as causing acute and chronic liver disease. Several prescription drugs, over-the-counter medications, dietary and/or supplementary agents, and herbal products are hepatotoxic. Drug-induced liver injury mimics other primary acute and chronic liver diseases and it should be considered in patients with hepatobiliary disease. Certain drugs result in specific histopathologic patterns of liver injury, which may help in sorting out the responsible drug. The diagnosis of drug-induced hepatotoxicity is challenging. It involves excluding other possible causes, careful medication history, the latent period between drug exposure and symptom onset and/or abnormal liver tests, and histopathologic findings.
药物性肝毒性认识不足，但越来越多地被认为可导致急性和慢性肝病。一些处方药、非处方药、饮食和/或补充剂以及草药产品都具有肝毒性。药物性肝损伤模仿其他原发性急性和慢性肝病，因此应考虑患有肝胆疾病的患者。某些药物可导致特定的肝损伤组织病理学模式，这有助于确定致病药物。药物性肝毒性的诊断具有挑战性。它需要排除其他可能的病因，仔细询问用药史、药物暴露与症状出现和/或异常肝功能之间的潜伏期，以及组织病理学发现。
