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载肾上腺髓质素微球-支架复合材料促进拔牙后牙槽骨改建的实验研究：大鼠模型。

Adrenomedullin delivery in microsphere-scaffold composite for remodeling of the alveolar bone following tooth extraction: an experimental study in the rat.

机构信息

Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun, China.

出版信息

Biomed Eng Online. 2013 Oct 8;12:99. doi: 10.1186/1475-925X-12-99.

DOI:10.1186/1475-925X-12-99
PMID:24099554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4124888/
Abstract

BACKGROUND

Alveolar ridge resorption, as a significant problem in implant and restorative dentistry, has long been considered as an inevitable outcome following tooth extraction. Recently, adrenomedullin (ADM) is reported to be able to stimulate the proliferation and migration of various cells including osteoblasts. The purpose of this study was to investigate the influence of local ADM application in the tooth extraction socket in vivo.

METHODS

Chitosan micropheres were developed by an emulsion-ionic cross-linking method for ADM delivery. Poly (L -lactic-co-glycolic) acid (PLGA) and nano-hydroxyapatite (nHA) were used to prepare scaffolds to contain the micrspheres with ADM. In vivo experiment was evaluated by transplanting the composite into the rat socket right after the incisor extraction. After 4, 8, 12 weeks implantation, radiographic and histological tests were carried out to evaluate the effect of released ADM on the alveolar bone.

RESULTS

The microspheres had a spherical structure and a relative rough and uniform surface, and the particle size was under a normal distribution, with the average diameter of 38.59 μm. The scaffolds had open and interconnected pores. In addition, the high porosity of the composite was 88.93%. Radiographic and histological examination revealed that the PLGA/nHA/CMs/ADM composite could accelerate the alveolar bone remodeling and reduce the residual ridge resorption compared with the PLGA/nHA/CMs scaffold.

CONCLUSIONS

The results of this study suggest that local application of ADM has the potential to preserve the residual alveolar ridge and accelerate the alveolar bone remodeling.

摘要

背景

牙槽嵴吸收是种植体和修复牙科中的一个重要问题，长期以来被认为是拔牙后不可避免的结果。最近，发现肾上腺髓质素 (ADM) 能够刺激包括成骨细胞在内的各种细胞的增殖和迁移。本研究旨在探讨局部应用 ADM 对拔牙窝内的影响。

方法

采用乳化-离子交联法制备 ADM 载药壳聚糖微球。聚（L-乳酸-co-乙醇酸）（PLGA）和纳米羟基磷灰石（nHA）被用来制备含有 ADM 微球的支架。通过将复合材料在切牙拔除后立即移植到大鼠牙槽窝中进行体内实验评估。植入后 4、8、12 周进行放射学和组织学测试，以评估释放的 ADM 对牙槽骨的影响。

结果

微球具有球形结构，表面相对粗糙且均匀，粒径呈正态分布，平均直径为 38.59μm。支架具有开放且相互连通的孔。此外，复合材料的高孔隙率为 88.93%。放射学和组织学检查表明，与 PLGA/nHA/CMs 支架相比，PLGA/nHA/CMs/ADM 复合材料可加速牙槽骨重塑并减少残余牙槽嵴吸收。

结论

本研究结果表明，局部应用 ADM 具有保留残余牙槽嵴和加速牙槽骨重塑的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/916a33e3e8ec/1475-925X-12-99-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/7ac5c8004656/1475-925X-12-99-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/8febed3dde74/1475-925X-12-99-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/53e70ff996b2/1475-925X-12-99-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/7fc676102eed/1475-925X-12-99-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/a39607ff0d59/1475-925X-12-99-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/f067ab8ff102/1475-925X-12-99-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/916a33e3e8ec/1475-925X-12-99-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/7ac5c8004656/1475-925X-12-99-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/8febed3dde74/1475-925X-12-99-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/53e70ff996b2/1475-925X-12-99-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/7fc676102eed/1475-925X-12-99-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/a39607ff0d59/1475-925X-12-99-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/f067ab8ff102/1475-925X-12-99-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14a/4124888/916a33e3e8ec/1475-925X-12-99-7.jpg

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