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机器人辅助根治性膀胱切除术的早期和晚期并发症:按尿流改道术式的标准化分析。

Early and late complications of robot-assisted radical cystectomy: a standardized analysis by urinary diversion type.

机构信息

Departments of Urologic Oncology and Biostatistics (NHR), City of Hope Cancer Center, Duarte, California.

Departments of Urologic Oncology and Biostatistics (NHR), City of Hope Cancer Center, Duarte, California.

出版信息

J Urol. 2014 Mar;191(3):681-7. doi: 10.1016/j.juro.2013.10.022. Epub 2013 Oct 4.

Abstract

PURPOSE

Minimally invasive surgical treatment for bladder cancer has gained popularity but standardized data on complications are lacking. Urinary diversion type contributes to complications and to our knowledge diversion types after minimally invasive cystectomy have not yet been compared. We evaluated perioperative complications stratified by urinary diversion type in patients treated with robot-assisted radical cystectomy.

MATERIALS AND METHODS

We analyzed the records of 209 consecutive patients who underwent robot-assisted radical cystectomy at our institution from 2003 to 2012 with respect to perioperative complications, including severity, time period (early and late) and diversion type. All complications were reviewed by academic urologists. Urinary diversion was also done. As outcome measurements and statistical analysis, univariate and multivariate logistic regression models were used to determine predictors of various complications.

RESULTS

The American Society of Anesthesiologists(®) (ASA) score was 3 or greater in 80% of patients and continent diversion was performed in 68%. Median followup was 35 months. Within 90 days 77.5% of patients experienced any complication and 32% experienced a major complication. The 90-day mortality rate was 5.3%. Most complications were gastrointestinal, infectious and hematological. On multivariate analysis patients with ileal conduit diversion had a decreased likelihood of complications compared to patients with Indiana pouch and orthotopic bladder substitute diversion despite the selection of a more comorbid population for conduit diversion. Continent diversion was associated with a higher likelihood of urinary tract infection. Our results are comparable to those of previously reported open and minimally invasive cystectomy series.

CONCLUSIONS

Open or minimally invasive cystectomy is a complex, morbid procedure. Urinary diversion is a significant contributor to complications, as is patient comorbidity. Although patients with an ileal conduit had more comorbidities, they experienced fewer complications than those with an orthotopic bladder substitute or Indiana pouch diversion.

摘要

目的

微创外科治疗膀胱癌已得到普及,但缺乏标准化的并发症数据。尿流改道类型会导致并发症,据我们所知,微创膀胱切除术的尿流改道类型尚未进行比较。我们评估了接受机器人辅助根治性膀胱切除术患者的尿流改道类型分层的围手术期并发症。

材料和方法

我们分析了 209 例连续患者的记录,他们于 2003 年至 2012 年在我们机构接受了机器人辅助根治性膀胱切除术,这些患者的围手术期并发症包括严重程度、时间(早期和晚期)和尿流改道类型。所有并发症均由学术泌尿科医生进行审查。还进行了尿流改道。作为结局测量和统计分析,我们使用单变量和多变量逻辑回归模型来确定各种并发症的预测因素。

结果

80%的患者美国麻醉师协会(ASA)评分≥3,68%的患者行可控性尿流改道。中位随访时间为 35 个月。90 天内,77.5%的患者发生任何并发症,32%的患者发生重大并发症。90 天死亡率为 5.3%。大多数并发症为胃肠道、感染和血液学并发症。多变量分析显示,与行 Indiana 袋和原位膀胱替代物尿流改道的患者相比,行回肠造口术的患者发生并发症的可能性较小,尽管为回肠造口术选择了更多合并症患者。可控性尿流改道与尿路感染的可能性增加有关。我们的结果与先前报道的开放和微创膀胱切除术系列结果相当。

结论

开放或微创膀胱切除术是一种复杂、病态的手术。尿流改道是并发症的一个重要原因,患者的合并症也是一个重要原因。尽管回肠造口术患者的合并症较多,但他们的并发症比原位膀胱替代物或 Indiana 袋尿流改道患者少。

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