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膀胱癌患者行机器人辅助根治性膀胱切除术并体外印第安纳袋可控性皮尿流改道术的功能结果和并发症。

Functional outcomes and complications in patients with bladder cancer undergoing robotic-assisted radical cystectomy with extracorporeal Indiana pouch continent cutaneous urinary diversion.

机构信息

Department of Urologic Oncology, City of Hope Cancer Center, Duarte, California 91010-3000, USA.

出版信息

Urology. 2012 May;79(5):1073-8. doi: 10.1016/j.urology.2011.12.050. Epub 2012 Mar 3.

Abstract

OBJECTIVE

To evaluate the functional outcomes and complications for patients with bladder cancer undergoing robotic-assisted laparoscopic radical cystectomy with Indiana pouch continent cutaneous urinary diversion.

METHODS

From February 2004 to March 2010, 34 patients underwent robotic-assisted laparoscopic radical cystectomy with Indiana pouch continent cutaneous urinary diversion reconstruction. After surgery, the complications were identified, categorized, and graded using an established 5-grade modification of the original Clavien grading system, and continence was assessed. Descriptive statistics were used in evaluating the outcomes. Fischer's exact test was used in the comparison of early and late Clavien grade III complications.

RESULTS

Overall, 175 (123 early and 52 late) complications after surgery were reported in 32 (94%) of 34 patients. Within 90 days of surgery, 31 (91%) of 34 patients experienced ≥ 1 early complication. Of 34 patients, 15 (44%) reported ≥ 1 late complications (>90 days). Most (85% and 69%, respectively) early and late complications were graded as minor (grade II or less). Fewer patients with early complications required an additional intervention (grade III) compared with patients with late complications (14% vs 31%; P = .116). The most common complication in both intervals was infection, reported in 22% and 37% of patients with early and late complications, respectively. The continence data for 31 patients at a mean follow-up of 20.1 months (median 12.0) showed that all but 1 patient (97%) had daytime and nighttime continence.

CONCLUSION

Patients undergoing robotic-assisted laparoscopic radical cystectomy with Indiana pouch continent cutaneous urinary diversion reconstruction have comparable complication rates and functional outcomes compared with patients in the open series.

摘要

目的

评估膀胱癌患者行机器人辅助腹腔镜根治性膀胱切除术联合印第安纳袋可控性皮瓣尿流改道术的功能结局和并发症。

方法

从 2004 年 2 月至 2010 年 3 月,34 例患者接受了机器人辅助腹腔镜根治性膀胱切除术联合印第安纳袋可控性皮瓣尿流改道术。术后确定并分类了并发症,并使用原始 Clavien 分级系统的 5 级改良版进行分级,同时评估了控尿情况。使用描述性统计来评估结果。Fisher 确切检验用于比较早期和晚期 Clavien Ⅲ级并发症。

结果

总体而言,34 例患者中有 32 例(94%)报告了 175 次(123 次早期和 52 次晚期)术后并发症。34 例患者中,有 31 例(91%)在手术后 90 天内出现≥1 次早期并发症。34 例患者中有 15 例(44%)报告了≥1 次晚期并发症(>90 天)。早期和晚期并发症中大多数(分别为 85%和 69%)为轻度(Ⅱ级或更低)。与晚期并发症患者相比,早期并发症患者需要进一步干预(Ⅲ级)的比例较低(14%比 31%;P=.116)。在两个时间段内最常见的并发症都是感染,分别有 22%和 37%的早期和晚期并发症患者发生感染。31 例患者在平均随访 20.1 个月(中位数 12.0)后的控尿数据显示,除 1 例患者外(97%),所有患者均有日间和夜间控尿能力。

结论

与开放系列手术患者相比,行机器人辅助腹腔镜根治性膀胱切除术联合印第安纳袋可控性皮瓣尿流改道术的患者具有相似的并发症发生率和功能结局。

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