抗病毒药物肌苷三磷酸和双膦酸盐对骨Paget病的比较效果。

Comparative effects of an antiviral drug, inosiplex, and diphosphonates in Paget's disease of bone.

作者信息

Kanis J A, Preston C J, Beard D J, Beneton M, Harris S, Russell R G

出版信息

Bone. 1985;6(2):69-72. doi: 10.1016/8756-3282(85)90309-6.

Abstract

The effects of the antiviral agent, inosiplex, were assessed in four patients with Paget's disease of bone. Treatment for 6 months did not suppress disease activity as judged by serum alkaline phosphatase and hydroxyprolinuria, and viral inclusions persisted in the one patient from whom a bone biopsy was taken. These results contrasted markedly with the suppressive effects of diphosphonate treatment in these same patients.

摘要

对四名骨Paget病患者评估了抗病毒药物肌苷磷酸钠的效果。根据血清碱性磷酸酶和羟脯氨酸尿症判断，治疗6个月并未抑制疾病活动，且在接受骨活检的一名患者中病毒包涵体持续存在。这些结果与双膦酸盐治疗对这些相同患者的抑制效果形成显著对比。