Campoli-Richards D M, Sorkin E M, Heel R C
Drugs. 1986 Nov;32(5):383-424. doi: 10.2165/00003495-198632050-00001.
Inosine pranobex is a synthetic compound formed from the p-acetamido benzoate salt of N-N dimethylamino-2-propanol and inosine in a 3:1 molar ratio. It has been reported to exert antiviral and antitumour activities in vivo which are secondary to an immunomodulating effect, and early results suggest beneficial clinical effects in several diseases and infections including mucocutaneous Herpes simplex infections, subacute sclerosing panencephalitis, genital warts, influenza, zoster, and type B viral hepatitis, as well as in homosexual men with persistent generalised lymphadenopathy. However, many of the studies have been preliminary in nature and deficient in design or in the reporting of their results. One must therefore conclude that while inosine pranobex may prove to be a valuable and innovative therapy for a number of diseases and infections for which no satisfactory therapy exist, further long term well controlled studies in larger numbers of patients are required before definitive conclusions about the efficacy of inosine pranobex in these disorders will be possible.
异丙肌苷是一种由N - N二甲基氨基 - 2 - 丙醇的对乙酰氨基苯甲酸盐与肌苷按3:1摩尔比形成的合成化合物。据报道，它在体内具有抗病毒和抗肿瘤活性，这些活性继发于免疫调节作用，早期结果表明其对多种疾病和感染有有益的临床效果，包括皮肤黏膜单纯疱疹感染、亚急性硬化性全脑炎、尖锐湿疣、流感、带状疱疹和乙型病毒性肝炎，以及患有持续性全身性淋巴结病的同性恋男性。然而，许多研究本质上是初步的，在设计或结果报告方面存在缺陷。因此，人们必须得出这样的结论：虽然异丙肌苷可能被证明是对许多尚无满意治疗方法的疾病和感染的一种有价值且创新的疗法，但在对异丙肌苷在这些疾病中的疗效得出明确结论之前，还需要对大量患者进行进一步的长期严格对照研究。
