Stack John, Ryan John, McCarthy Geraldine
1Department of Rheumatology, Cork University Hospital, Cork, Ireland; and 2Department of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland.
Am J Ther. 2015 Sep-Oct;22(5):e151-7. doi: 10.1097/01.mjt.0000433937.07244.e1.
Colchicine is an ancient drug that is used for symptomatic relief in a wide range of inflammatory diseases including gout, Behçet syndrome, and familial Mediterranean fever. Recognition of its antiinflammatory properties and of its unpleasant gastrointestinal side effects date back thousands of years. Despite this, uncertainty remains concerning its mechanism of action and very few randomized controlled trials have been carried out to examine its safety and efficacy to date. Although it is an effective drug, its use is hindered by a very narrow therapeutic index. This review attempts to summarize recent developments concerning the use of colchicine in the treatment of gout with particular focus on its mechanism of action and toxicity.
秋水仙碱是一种古老的药物，用于缓解多种炎症性疾病的症状，包括痛风、白塞病和家族性地中海热。人们认识到它的抗炎特性及其令人不适的胃肠道副作用可以追溯到数千年前。尽管如此，其作用机制仍存在不确定性，迄今为止很少有随机对照试验来检验其安全性和有效性。虽然它是一种有效的药物，但其治疗指数非常窄，这限制了它的使用。本综述试图总结秋水仙碱在痛风治疗中的最新进展，特别关注其作用机制和毒性。
