1] Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. [2] The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK. [3].
Nat Rev Microbiol. 2013 Nov;11(11):761-76. doi: 10.1038/nrmicro3118. Epub 2013 Oct 8.
Over the past decade, considerable advances have been made in understanding the molecular mechanisms that underpin the arms race between plant pathogens and their hosts. Alongside genomic, bioinformatic, proteomic, biochemical and cell biological analyses of plant-pathogen interactions, three-dimensional structural studies of virulence proteins deployed by pathogens to promote infection, in some cases complexed with their plant cell targets, have uncovered key insights into the functions of these molecules. Structural information on plant immune receptors, which regulate the response to pathogen attack, is also starting to emerge. Structural studies of bacterial plant pathogen-host systems have been leading the way, but studies of filamentous plant pathogens are gathering pace. In this Review, we summarize the key developments in the structural biology of plant pathogen-host interactions.
在过去的十年中，人们在理解植物病原体与其宿主之间的军备竞赛所依赖的分子机制方面取得了重大进展。除了对植物-病原体相互作用进行基因组、生物信息学、蛋白质组学、生物化学和细胞生物学分析外，对病原体用于促进感染的毒力蛋白的三维结构研究，以及在某些情况下与植物细胞靶标形成复合物的研究，揭示了这些分子功能的关键见解。调节对病原体攻击反应的植物免疫受体的结构信息也开始出现。细菌植物病原体-宿主系统的结构研究一直处于领先地位，但丝状植物病原体的研究也在加速。在这篇综述中，我们总结了植物病原体-宿主相互作用的结构生物学的主要进展。
