The Sainsbury Laboratory, Norwich, UK.
Cell Microbiol. 2010 Jun;12(6):705-15. doi: 10.1111/j.1462-5822.2010.01471.x. Epub 2010 Mar 31.
Filamentous pathogens, such as plant pathogenic fungi and oomycetes, secrete an arsenal of effector molecules that modulate host innate immunity and enable parasitic infection. It is now well accepted that these effectors are key pathogenicity determinants that enable parasitic infection. In this review, we report on the most interesting features of a representative set of filamentous pathogen effectors and highlight recent findings. We also list and describe all the linear motifs reported to date in filamentous pathogen effector proteins. Some of these motifs appear to define domains that mediate translocation inside host cells.
丝状病原体,如植物病原真菌和卵菌,会分泌出一整套效应分子,来调节宿主先天免疫并使其感染寄生。现在人们普遍认为,这些效应子是决定寄生感染的关键致病性决定因素。在这篇综述中,我们报告了一组有代表性的丝状病原体效应子的最有趣的特征,并强调了最近的发现。我们还列出并描述了迄今为止在丝状病原体效应蛋白中报道的所有线性基序。其中一些基序似乎定义了介导宿主细胞内易位的结构域。