一锅一步串联生物催化氧化还原拆分 2-羟基酸的外消旋混合物。
One-pot, single-step deracemization of 2-hydroxyacids by tandem biocatalytic oxidation and reduction.
机构信息
Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
出版信息
Chem Commun (Camb). 2013 Nov 25;49(91):10706-8. doi: 10.1039/c3cc46240d.
PMID:24100587
Abstract
A facile and efficient one-pot, single-step method for deracemizing a broad range of 2-hydroxyacids to (R)-2-hydroxyacids was established by combination of resting cells of an (S)-hydroxyacid dehydrogenase-producing microorganism and an (R)-ketoacid reductase-producing microorganism.
摘要
建立了一种简便、高效的一锅一步法，通过（S）-羟基酸脱氢酶产生微生物的休眠细胞和（R）-酮酸还原酶产生微生物的组合，将广泛的 2-羟基酸外消旋化为（R）-2-羟基酸。
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