Reis-Santos Barbara, Gomes Teresa, Horta Bernardo Lessa, Maciel Ethel Leonor Noia
J Bras Nefrol. 2013 Jul-Sep;35(3):206-13. doi: 10.5935/0101-2800.20130033.
Tuberculosis (TB) prevalence in subjects with kidney transplantation (KTX) is greater than in general population. We aimed to realize a systematic review and meta-analysis of prevalence of TB in KTX (TB-KTX).
We searched by the texts in electronic databases and references were reviewed. We estimated the pooled prevalence of TB-KTX subjects and we also conducted analysis by meta-regression. TB prevalence in general population (0.18%; 95% IC = 0.16-0.20) was reference to comparison.
We screened 253 papers, which 41 studies entered in analysis. The pooled prevalence of TB-KTX was 2.51% (95% CI = 2.17-2.85). In the meta-regression sample size > 2.501 subjects and high prevalence of TB in general population remained associated with TB-KTX.
TB prevalence in KTX was 14 times greater than in general population. Thus, we highlighted the necessity that planning of measures for prevention and control of TB for this population should be agenda in discussions of health sector.
肾移植（KTX）受者中的结核病（TB）患病率高于普通人群。我们旨在对肾移植受者中的结核病（TB-KTX）患病率进行系统评价和荟萃分析。
通过电子数据库中的文本进行检索并对参考文献进行审查。我们估计了TB-KTX受者的合并患病率，并通过Meta回归进行分析。以普通人群中的结核病患病率（0.18%；95%IC=0.16-0.20）作为对照。
我们筛选了253篇论文，其中41项研究纳入分析。TB-KTX的合并患病率为2.51%（95%CI=2.17-2.85）。在Meta回归中，样本量>2501例受试者以及普通人群中结核病的高患病率仍与TB-KTX相关。
肾移植受者中的结核病患病率比普通人群高14倍。因此，我们强调针对该人群制定结核病预防和控制措施应成为卫生部门讨论的议程。
