Maciel Mônica Maria Moreira Delgado, Ceccato Maria das Graças, Carvalho Wânia da Silva, Navarro Pedro Daibert de, Farah Kátia de Paula, Miranda Silvana Spindola de
. Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte (MG) Brasil.
. Grupo de Transplante Renal, Hospital de Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte (MG) Brasil.
J Bras Pneumol. 2018 Nov-Dec;44(6):461-468. doi: 10.1590/S1806-37562017000000367.
To estimate the prevalence of latent Mycobacterium tuberculosis infection (LTBI) in renal transplant recipients and to assess sociodemographic, behavioral, and clinical associations with positive tuberculin skin test (TST) results.
This was a cross-sectional study of patients aged ≥ 18 years who underwent renal transplantation at the Renal Transplant Center of the Federal University of Minas Gerais Hospital das Clínicas, located in the city of Belo Horizonte, Brazil. We included renal transplant recipients who underwent the TST between January 2011 and July 2013. If the result of the first TST was negative, a second TST was administered. Bivariate and multivariate analyses using logistic regression were used to determine factors associated with positive TST results.
The sample included 216 patients. The prevalence of LTBI was 18.5%. In the multivariate analysis, history of contact with a tuberculosis case and preserved graft function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2) were associated with positive TST results. TST induration increased by 5.8% from the first to the second test, which was considered significant (p = 0.012).
The prevalence of LTBI was low in this sample of renal transplant recipients. The TST should be administered if renal graft function is preserved. A second TST should be administered if the first TST is negative.
评估肾移植受者中潜伏性结核分枝杆菌感染（LTBI）的患病率，并评估社会人口学、行为及临床因素与结核菌素皮肤试验（TST）阳性结果之间的关联。
这是一项横断面研究，研究对象为年龄≥18岁、在位于巴西贝洛奥里藏特市的米纳斯吉拉斯联邦大学临床医院肾脏移植中心接受肾移植的患者。我们纳入了在2011年1月至2013年7月期间接受TST的肾移植受者。如果首次TST结果为阴性，则进行第二次TST。采用逻辑回归进行双变量和多变量分析，以确定与TST阳性结果相关的因素。
样本包括216例患者。LTBI的患病率为18.5%。在多变量分析中，与结核病病例接触史及移植肾功能良好（估计肾小球滤过率≥60 mL/min/1.73 m2）与TST阳性结果相关。从第一次试验到第二次试验，TST硬结增大了5.8%，这被认为具有显著性（p = 0.012）。
在该肾移植受者样本中，LTBI的患病率较低。如果移植肾功能良好，应进行TST。如果首次TST为阴性，则应进行第二次TST。
