Bolognesi D P, Fischinger P J
Cancer Res. 1985 Sep;45(9 Suppl):4700s-4705s.
Overwhelming evidence has been obtained over the past 2 years that human T-cell leukemia virus type III (HTLV-III) is the primary cause of acquired immunodeficiency syndrome. The direct cytopathic effect of the virus on T4 helper cells demonstrated in vitro is probably responsible for the depletion of this critical population of cells in affected individuals which results in a series of devastating immunological abnormalities. It follows that any approaches effective in suppressing the virulent virus would be of benefit to the infected patient. The vast amount of knowledge about retroviruses in general, and the rapidly accumulating information about HTLV-III in particular, makes it likely that a targeted approach for development of antiviral agents will bear fruit. General strategies further making use of chemical and biological agents as well as genetic manipulations are discussed.
在过去两年中已获得大量证据，表明人类III型T细胞白血病病毒（HTLV-III）是获得性免疫缺陷综合征的主要病因。该病毒在体外对T4辅助细胞的直接细胞病变效应，可能是导致受感染个体中这一关键细胞群体耗竭的原因，而这会引发一系列毁灭性的免疫异常。因此，任何有效抑制这种强毒病毒的方法都将对受感染患者有益。总体而言，关于逆转录病毒的大量知识，尤其是关于HTLV-III的迅速积累的信息，使得开发抗病毒药物的靶向方法很可能会取得成果。本文讨论了进一步利用化学和生物制剂以及基因操作的一般策略。
