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1
Nucleotide sequences of five anti-lysozyme monoclonal antibodies.五种抗溶菌酶单克隆抗体的核苷酸序列。
EMBO J. 1985 Feb;4(2):393-8. doi: 10.1002/j.1460-2075.1985.tb03641.x.
2
Nucleotide sequence of messenger RNA encoding VHDJH and VKJK of a highly conserved idiotype-defined primary response anti-hapten antibody.编码高度保守的独特型定义的初级反应抗半抗原抗体的VHDJH和VKJK的信使核糖核酸的核苷酸序列。
J Immunol. 1992 Dec 15;149(12):3944-52.
3
Amino acid sequence of a phosphocholine-binding antibody from an immune defective CBA/N mouse employing the T15 VH region associated with unusual DH, JH, and V kappa segments.利用与异常重链多样性基因（DH）、重链连接基因（JH）和κ轻链可变区（Vκ）片段相关的T15重链可变区（VH），从免疫缺陷的CBA/N小鼠中获得的一种磷酸胆碱结合抗体的氨基酸序列。
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8
Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B cells.小鼠IgM抗IgG单克隆自身抗体（类风湿因子）的可变区序列。对IgM抗IgG B细胞高频率的结构解释。
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10
Mouse Vk gene classification by nucleic acid sequence similarity.基于核酸序列相似性对小鼠Vk基因进行分类。
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本文引用的文献

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IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts.针对磷酸胆碱的IgG抗体比其对应的IgM抗体表现出更多样性。
Nature. 1981 May 7;291(5810):29-34. doi: 10.1038/291029a0.
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mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification.信使核糖核酸序列定义了对2-苯基恶唑酮异常受限的免疫球蛋白G反应及其早期多样化。
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VH families in the antibody response to p-azophenylarsonate: correlation between serology and amino acid sequence.对对氨基苯砷酸抗体应答中的VH家族：血清学与氨基酸序列之间的相关性
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五种抗溶菌酶单克隆抗体的核苷酸序列。

Nucleotide sequences of five anti-lysozyme monoclonal antibodies.

作者信息

Darsley M J, Rees A R

出版信息

EMBO J. 1985 Feb;4(2):393-8. doi: 10.1002/j.1460-2075.1985.tb03641.x.

DOI:10.1002/j.1460-2075.1985.tb03641.x
PMID:2410256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC554198/
Abstract

The nucleotide sequences of the heavy and light chain immunoglobulin mRNAs derived from five hybridomas (Gloop 1-5) secreting IgGs specific for the loop region of hen egg lysozyme were determined. These monoclonal antibodies recognise three distinct but overlapping epitopes within the loop region. The sequences of two pairs of antibodies with indistinguishable fine specificities were similar in both chains whereas the sequences of antibodies of non-identical specificities were very different. It is proposed that the D-segments expressed in two of the antibodies (Gloop3 and Gloop4) are the products of one, or perhaps two, previously unidentified germ line D-genes. Gloop1 and Gloop2 use a D-segment previously identified in antibodies specific for the hapten 2-phenyloxazolone; however it is recombined in a different reading frame in the anti-lysozyme antibodies, producing a different amino acid sequence.

摘要

测定了来自5种杂交瘤（Gloop 1 - 5）的重链和轻链免疫球蛋白mRNA的核苷酸序列，这些杂交瘤分泌对鸡卵溶菌酶环区具有特异性的IgG。这些单克隆抗体识别环区内三个不同但重叠的表位。两对具有难以区分的精细特异性的抗体在两条链上的序列相似，而具有不同特异性的抗体序列则非常不同。有人提出，在两种抗体（Gloop3和Gloop4）中表达的D片段是一个或可能两个先前未鉴定的种系D基因的产物。Gloop1和Gloop2使用先前在对半抗原2 - 苯基恶唑酮具有特异性的抗体中鉴定出的一个D片段；然而，它在抗溶菌酶抗体中以不同的阅读框进行重组，产生不同的氨基酸序列。