单个VH基因片段编码对磷酸胆碱的免疫反应：体细胞突变与抗体类别相关。 - Suppr

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超能文献

A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody.

作者信息

Crews S, Griffin J, Huang H, Calame K, Hood L

出版信息

Cell. 1981 Jul;25(1):59-66. doi: 10.1016/0092-8674(81)90231-2.

DOI:10.1016/0092-8674(81)90231-2

PMID:6791833

Abstract

摘要

相似文献

A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody.单个VH基因片段编码对磷酸胆碱的免疫反应：体细胞突变与抗体类别相关。

Cell. 1981 Jul;25(1):59-66. doi: 10.1016/0092-8674(81)90231-2.

Specific H chain junctional diversity may be required for non-T15 antibodies to bind phosphorylcholine.非T15抗体结合磷酸胆碱可能需要特定的重链连接多样性。

J Immunol. 1988 Aug 15;141(4):1267-72.

The immune response of BALB/c mice to phosphorylcholine is restricted to a limited number of VH- and VL-isotypes.BALB/c小鼠对磷酸胆碱的免疫反应仅限于有限数量的重链可变区（VH）和轻链可变区（VL）同种型。

Mol Immunol. 1981 Dec;18(12):1027-33. doi: 10.1016/0161-5890(81)90018-3.

Polymorphism in anti-phosphocholine antibodies reflecting evolution of immunoglobulin families.抗磷酸胆碱抗体中的多态性反映了免疫球蛋白家族的进化。

J Exp Med. 1983 Jan 1;157(1):98-113. doi: 10.1084/jem.157.1.98.

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts.针对磷酸胆碱的IgG抗体比其对应的IgM抗体表现出更多样性。

Nature. 1981 May 7;291(5810):29-34. doi: 10.1038/291029a0.

Amino acid sequence of a phosphocholine-binding antibody from an immune defective CBA/N mouse employing the T15 VH region associated with unusual DH, JH, and V kappa segments.利用与异常重链多样性基因（DH）、重链连接基因（JH）和κ轻链可变区（Vκ）片段相关的T15重链可变区（VH），从免疫缺陷的CBA/N小鼠中获得的一种磷酸胆碱结合抗体的氨基酸序列。

J Immunol. 1984 Mar;132(3):1544-9.

Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies.点突变导致IgM和IgG2a抗磷酸胆碱抗体的体细胞多样化。

J Exp Med. 1988 Mar 1;167(3):954-73. doi: 10.1084/jem.167.3.954.

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH.免疫球蛋白重链可变区基因由三段DNA片段组成：VH、D和JH。

Cell. 1980 Apr;19(4):981-92. doi: 10.1016/0092-8674(80)90089-6.

Polymorphism in immunoglobulin heavy chains suggesting gene conversion.免疫球蛋白重链中的多态性提示基因转换。

Proc Natl Acad Sci U S A. 1982 May;79(10):3280-4. doi: 10.1073/pnas.79.10.3280.

The generation of diversity in phosphorylcholine-binding antibodies.磷酸胆碱结合抗体多样性的产生。

Adv Immunol. 1984;35:1-37. doi: 10.1016/s0065-2776(08)60572-6.

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