2-5A作用的类似物抑制剂：对干扰素介导的脑心肌炎病毒复制抑制作用的影响
Analogue inhibitor of 2-5A action: effect on the interferon-mediated inhibition of encephalomyocarditis virus replication.
作者信息
Watling D, Serafinowska H T, Reese C B, Kerr I M
出版信息
EMBO J. 1985 Feb;4(2):431-6. doi: 10.1002/j.1460-2075.1985.tb03647.x.
Chemically synthesised CH3Sp(A2'p)2A2'pp3'OCH3 has been used to assess the importance of the ppp(A2'p)nA (n greater than or equal to 2: 2-5A) system in the antiviral action of interferon against encephalomyocarditis virus (EMC). It inhibits activation of the 2-5A-dependent RNase by 2-5A in intact mouse L929 cells and cell-free systems. In interferon-treated, EMC-infected L929 cells it inhibits 2-5A-mediated rRNA cleavage and partially restores EMC RNA synthesis and virus yield. Activation of the 2-5A-dependent RNase must, therefore, play some part in interferon action against the growth of EMC virus in such cells.
化学合成的CH3Sp(A2'p)2A2'pp3'OCH3已被用于评估ppp(A2'p)nA（n大于或等于2：2-5A）系统在干扰素抗脑心肌炎病毒（EMC）抗病毒作用中的重要性。它在完整的小鼠L929细胞和无细胞系统中抑制2-5A对2-5A依赖性核糖核酸酶的激活。在经干扰素处理、感染EMC的L929细胞中，它抑制2-5A介导的rRNA切割，并部分恢复EMC RNA合成和病毒产量。因此，2-5A依赖性核糖核酸酶的激活在干扰素对这类细胞中EMC病毒生长的作用中必定起到了一定作用。
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