在经干扰素处理的脑心肌炎病毒感染的L细胞中2-5A的自然出现。
Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells.
作者信息
Williams B R, Golgher R R, Brown R E, Gilbert C S, Kerr I M
出版信息
Nature. 1979 Dec 6;282(5739):582-6. doi: 10.1038/282582a0.
DOI:10.1038/282582a0
PMID:95208
Abstract
Until now the interferon-mediated 2'-5' adenine oligonucleotide inhibitors (2-5A) of cell-free protein synthesis have not been detected in intact cells. Here we report their natural occurrence in interferon-treated, EMC virus-infected mouse L cells in amounts consistent with the idea that they play a part in the inhibition of virus growth.
摘要
迄今为止，在完整细胞中尚未检测到干扰素介导的无细胞蛋白质合成的2'-5'腺嘌呤寡核苷酸抑制剂（2-5A）。在此，我们报告它们在经干扰素处理、感染脑心肌炎病毒（EMC病毒）的小鼠L细胞中天然存在，其含量与它们在抑制病毒生长中起作用的观点相符。
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