Academic Department of Biomedicine and Prevention, Section of Gynecology and Obstetrics, University Tor Vergata, Rome, Italy.
Am J Reprod Immunol. 2013 Nov;70(5):343-6. doi: 10.1111/aji.12156. Epub 2013 Sep 16.
To investigate the possible relationship between human papillomavirus (HPV) infection and recurrent miscarriage (RM).
In this retrospective case-control study, 49 women with unexplained RM (Group 1 - cases) and 475 women without any miscarriage and with at least one pregnancy at term (Group 2 - controls) were checked for cervical HPV infection through Hybrid Capture(®) II (HC 2) or polymerase chain reaction (PCR).
HPV+ DNA tests were detected in 13 (26.53%) RM women and in 294 (61.89%) control women (P < 0.001). The prevalence rate in HPV+DNA tests was significantly different in the 30-39 years age range. No differences between groups were detected in HPV types, nor in the cytological and histological findings.
Women with RM have a lower prevalence of HPV+DNA tests than controls. This suggests that immune reactivity potentially leading to RM could be in some way protective against genital HPV infection.
研究人乳头瘤病毒（HPV）感染与复发性流产（RM）之间可能存在的关系。
在这项回顾性病例对照研究中，通过 Hybrid Capture(®) II（HC 2）或聚合酶链反应（PCR）检查 49 名不明原因 RM 妇女（第 1 组-病例）和 475 名无任何流产且至少有一次足月妊娠的妇女（第 2 组-对照组）的宫颈 HPV 感染情况。
RM 妇女中 13 例（26.53%）和对照组妇女 294 例（61.89%）检测到 HPV+DNA 试验阳性（P<0.001）。HPV+DNA 试验在 30-39 岁年龄组的阳性率差异有统计学意义。HPV 类型、细胞学和组织学发现两组间无差异。
RM 妇女 HPV+DNA 试验的阳性率低于对照组。这表明，可能导致 RM 的免疫反应在某种程度上对生殖道 HPV 感染具有保护作用。
