男性生育异常与人类乳头瘤病毒感染风险的关系：一项荟萃分析。
The risk of human papillomavirus infection for male fertility abnormality: a meta-analysis.
机构信息
Department of Epidemiology, School of Public Health, Southern Medical University, Guangdong Provincial Key Laboratory of Tropical Disease Research, Guangzhou 510515, China.
出版信息
Asian J Androl. 2018 Sep-Oct;20(5):493-497. doi: 10.4103/aja.aja_77_17.
Human papillomavirus (HPV) is the most common sexually transmitted virus in males and females worldwide; yet its impact upon male fertility remains unclear. The objective of this study was to evaluate the potential impact of HPV infection in semen on male fertility abnormality. A systematic literature search was performed in PubMed, Medline, Embase, Web of Science, and the Cochrane Library database for relevant publications up to May 6, 2017. The odds ratio (OR), and its corresponding 95% confidence interval (CI), was selected to represent the effect size. Statistical analysis was conducted using STATA 12.0. In total, eight articles, providing data on 1955 participants, were included in this meta-analysis. Collectively, the data suggested that HPV infection of semen was a risk factor for male fertility abnormality with an OR of 3.02 (95% CI: 2.11-4.32; I = 6.9%). Sensitivity analysis revealed that the results of this study were robust. In conclusion, HPV infection of semen represents a risk factor for male fertility abnormality.
人乳头瘤病毒（HPV）是全球男性和女性中最常见的性传播病毒；然而，其对男性生育力的影响尚不清楚。本研究的目的是评估精液中 HPV 感染对男性生育异常的潜在影响。系统检索了 PubMed、Medline、Embase、Web of Science 和 Cochrane Library 数据库，以获取截至 2017 年 5 月 6 日的相关文献。选用比值比（OR）及其相应的 95%置信区间（CI）来表示效应大小。使用 STATA 12.0 进行统计分析。共纳入 8 篇文章，共计 1955 名参与者的数据纳入本荟萃分析。总的来说，数据表明精液中的 HPV 感染是男性生育异常的一个危险因素，OR 为 3.02（95%CI：2.11-4.32；I = 6.9%）。敏感性分析表明，本研究的结果是稳健的。总之，精液中的 HPV 感染是男性生育异常的一个危险因素。
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