Corbí A L, Cortes C, Bousquet J, Basomba A, Cistero A, Garcia-Selles J, d'Amato G, Carreira J
Int Arch Allergy Appl Immunol. 1985;77(4):377-83. doi: 10.1159/000233812.
Common antigenic determinants have been observed between Parietaria and Urtica dioica pollen. The four Parietaria pollens selected (P. judaica, P. officinalis, P. lusitanica and P. mauritanica) are shown to possess a high allergenic homology. IgE-binding structures, homologous to the P. judaica main allergenic polypeptide (Pj10), were found in the other species by immunodetection. Monoclonal antibodies specific to the Pj10 polypeptide recognized proteins from the four Parietaria pollens. Skin prick test and RAST inhibition yielded results that also indicated a high allergenic cross-reactivity among these pollens, with homologous peptides bearing common antigenic and allergenic determinants. On the other hand, U. dioica pollen showed only a slight allergenic similarity to Parietaria. The potential allergenic activity of these pollens is discussed.
已观察到墙草属花粉和异株荨麻花粉之间存在共同的抗原决定簇。所选取的四种墙草属花粉（犹太墙草、药用墙草、葡萄牙墙草和毛里塔尼亚墙草）显示出高度的变应原同源性。通过免疫检测发现，其他物种中存在与犹太墙草主要变应原多肽（Pj10）同源的IgE结合结构。针对Pj10多肽的单克隆抗体识别出了四种墙草属花粉中的蛋白质。皮肤点刺试验和放射性变应原吸附试验抑制结果也表明，这些花粉之间存在高度的变应原交叉反应性，具有带有共同抗原和变应原决定簇的同源肽。另一方面，异株荨麻花粉与墙草属仅表现出轻微的变应原相似性。文中讨论了这些花粉的潜在变应原活性。
