Meldrum L A, Burnstock G
J Pharm Pharmacol. 1985 Jun;37(6):432-4. doi: 10.1111/j.2042-7158.1985.tb03031.x.
In the guinea-pig bladder, contractile responses to substance P (0.3 microM) and VIP (3 microM) were unaffected by P2-purinoceptor desensitization with alpha,beta-methylene ATP (3 X 10(-6) M), while the responses to stimulation of the non-cholinergic excitatory nerves (4-16 Hz) were abolished. The evidence presented suggests that ATP or a related purine nucleotide, and not VIP or substance P, is responsible for the non-cholinergic excitatory component of the nerve-mediated response.
在豚鼠膀胱中，用α,β-亚甲基ATP（3×10⁻⁶ M）使P2嘌呤受体脱敏后，对P物质（0.3微摩尔）和血管活性肠肽（3微摩尔）的收缩反应未受影响，而对非胆碱能兴奋性神经刺激（4 - 16赫兹）的反应则被消除。所提供的证据表明，神经介导反应的非胆碱能兴奋性成分是由ATP或一种相关嘌呤核苷酸而非血管活性肠肽或P物质引起的。
