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Investigations into the identity of the non-adrenergic, non-cholinergic excitatory transmitter in the smooth muscle of chicken rectum.

作者信息

Meldrum L A, Burnstock G

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;81(2):307-9. doi: 10.1016/0742-8413(85)90011-8.

DOI:10.1016/0742-8413(85)90011-8
PMID:2410183
Abstract

ATP and substance P were examined as possible mediators of non-adrenergic, non-cholinergic excitatory transmission in chicken rectum. ATP and the non-degradable ATP analogue, alpha, beta-methylene ATP, mimicked the response to nerve stimulation. Substance P either produced a maintained contraction after a long latency or was inactive. After desensitization of the P2-purinoceptor by alpha, beta-methylene ATP, the responses to ATP and nerve stimulation were abolished, while the response to carbachol was little affected. It is concluded that ATP may be the transmitter in non-adrenergic, non-cholinergic excitatory nerves supplying the chicken rectum.

摘要

相似文献

1
Investigations into the identity of the non-adrenergic, non-cholinergic excitatory transmitter in the smooth muscle of chicken rectum.
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2
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引用本文的文献

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Membrane current responses to externally-applied ATP in the longitudinal muscle of the chicken rectum.鸡直肠纵肌对外源性ATP的膜电流反应。
Br J Pharmacol. 1993 Sep;110(1):87-94. doi: 10.1111/j.1476-5381.1993.tb13775.x.
2
Membrane potential responses to ATP applied by pressure ejection in the longitudinal muscle of chicken rectum.鸡直肠纵肌中通过压力喷射施加ATP时的膜电位反应。
Br J Pharmacol. 1988 Dec;95(4):1157-64. doi: 10.1111/j.1476-5381.1988.tb11751.x.
3
Development before and after hatching of non-cholinergic excitatory innervation to the rectum via Remak's nerve in the fowl.
家禽中通过雷马克神经对直肠的非胆碱能兴奋性神经支配在孵化前后的发育情况。
Br J Pharmacol. 1988 Nov;95(3):844-50. doi: 10.1111/j.1476-5381.1988.tb11713.x.
4
Some membrane properties of the circular muscle of chicken rectum and its non-adrenergic non-cholinergic innervation.鸡直肠环行肌的一些膜特性及其非肾上腺素能非胆碱能神经支配
J Physiol. 1988 Jul;401:417-35. doi: 10.1113/jphysiol.1988.sp017170.
5
Effects of prolonged exposure to alpha,beta-methylene ATP on non-adrenergic, non-cholinergic excitatory transmission in the rectum of the chicken.长期暴露于α,β-亚甲基ATP对鸡直肠非肾上腺素能、非胆碱能兴奋性传递的影响。
Br J Pharmacol. 1988 May;94(1):9-18. doi: 10.1111/j.1476-5381.1988.tb11494.x.
6
Investigation of the selectivity of alpha, beta-methylene ATP in inhibiting vascular responses of the rat in vivo and in vitro.α,β-亚甲基三磷酸腺苷对大鼠体内外血管反应抑制作用的选择性研究。
Br J Pharmacol. 1990 Apr;99(4):820-4. doi: 10.1111/j.1476-5381.1990.tb13013.x.