微小RNA-196a2基因多态性与结直肠癌易感性关联的荟萃分析。

Meta-analysis of the association between a polymorphism in microRNA-196a2 and susceptibility to colorectal cancer.

作者信息

Shi Ke-Qing, Lin Zhuo, Li De-Wei, Fang Yu-Xiao, Gao Jian, Deng Zhu-Jun, Chen Li, Li Gui-Ling, Wu Jian-Min, Tang Kai-Fu

机构信息

Department of Infection and Liver Diseases, Institution of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, China.

出版信息

Onkologie. 2013;36(10):560-5. doi: 10.1159/000355158. Epub 2013 Sep 16.

DOI:10.1159/000355158

PMID:24107909

Abstract

BACKGROUND/AIMS: To accurately evaluate the impact of the C/T polymorphism in microRNA (miRNA)-196a2 on the colorectal cancer (CRC) risk, by meta-analysis.

METHODS

An electronic search for articles was conducted in PubMed, EMBASE, ISI Web of Science, and the Cochrane Library. The pooled odds ratio (OR) and its 95% confidence interval (CI) were used to assess the association through meta-analysis.

RESULTS

5 studies were used for analysis. The results showed a significant association between the miRNA-196a2 C/T polymorphism and CRC risk in the genetic models (C vs. T: OR = 1.168, 95% CI = 1.106-1.282, p = 0.001; CC vs. TT: OR = 1.368, 95% CI = 1.132-1.654, p = 0.001; TC/CC vs. TT: OR = 1.206, 95% = CI 1.035-1.405, p = 0.016; CC vs.

TC/TT: OR = 1.254, 95% CI = 1.077-1.461, p = 0.004), with the exception of the TC-versus-TT model (TC vs. TT: OR = 1.130, 95% CI = 0.961-1.329, p = 0.138). In a subgroup analysis based on ethnicity, we identified a significant overrepresentation of the polymorphism in individuals of Asian ethnicity.

CONCLUSION

This meta-analysis indicates a significant association between the miRNA-196a2 polymorphism and CRC risk.

摘要

背景/目的：通过荟萃分析准确评估微小RNA（miRNA）-196a2中C/T多态性对结直肠癌（CRC）风险的影响。

方法

在PubMed、EMBASE、ISI科学网和Cochrane图书馆中进行电子文献检索。通过荟萃分析，使用合并优势比（OR）及其95%置信区间（CI）来评估关联性。

结果

5项研究用于分析。结果显示，在遗传模型中，miRNA-196a2 C/T多态性与CRC风险之间存在显著关联（C与T：OR = 1.168，95%CI = 1.106 - 1.282，p = 0.001；CC与TT：OR = 1.368，95%CI = 1.132 - 1.654，p = 0.001；TC/CC与TT：OR = 1.206，95%CI = 1.035 - 1.405，p = 0.016；CC与TC/TT：OR = 1.254，95%CI = 1.077 - 1.461，p = 0.004），TC与TT模型除外（TC与TT：OR = 1.130，95%CI = 0.961 - 1.329，p = 0.138）。在基于种族的亚组分析中，我们发现该多态性在亚洲种族个体中显著过度呈现。