Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
West China School of Medicine, Sichuan University, Sichuan, China.
Cancer Biomark. 2013 Jan 1;13(6):457-64. doi: 10.3233/CBM-140389.
MicroRNAs (miRNAs) are small non-coding RNAs of 20-22 nucleotides in length, which regulate the translation or degradation of human messenger RNA (mRNA). MiRNAs involve in the regulation of most biological processes, as well as human diverse diseases including cancer. Recently, many studies investigated the association between miR-196a2 rs11614913 polymorphism and colorectal cancer (CRC), which showed inconclusive results.
METHODOLOGY/PRINCIPAL FINDINGS: We conducted a meta-analysis of 6 studies that included 1800 cases and 2329 controls. There was a statistically decreased risk of CRC in dominant model, recessive model and homozygous model. In the Asian group, significantly decreased susceptibility of CRC was found in allele model, dominant model, recessive model and homozygous model. As for the Caucasian group, none of genetic models demonstrates significant association between miR-196a2 rs11614913 polymorphism and susceptibility of CRC.
These findings supported that miR-196a2 rs11614913 polymorphism may contribute to the susceptibility of CRC.
MicroRNAs（miRNAs）是长度为 20-22 个核苷酸的小非编码 RNA，可调节人类信使 RNA（mRNA）的翻译或降解。miRNAs 参与大多数生物过程的调节，以及人类多种疾病，包括癌症。最近，许多研究调查了 miR-196a2 rs11614913 多态性与结直肠癌（CRC）之间的关联，结果尚无定论。
方法/主要发现：我们对包括 1800 例病例和 2329 例对照的 6 项研究进行了荟萃分析。在显性模型、隐性模型和纯合子模型中，CRC 的风险统计学降低。在亚洲人群中，在等位基因模型、显性模型、隐性模型和纯合子模型中，CRC 的易感性显著降低。对于白人群体，miR-196a2 rs11614913 多态性与 CRC 的易感性之间没有任何遗传模型显示出显著的关联。
这些发现支持 miR-196a2 rs11614913 多态性可能导致 CRC 的易感性。
