Zhong Liang, Su Boyang, Zhang Jun-Mei, Leo Hwa Liang, Tan Ru San
Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:703-6. doi: 10.1109/EMBC.2013.6609597.
Investigating the intra-ventricular flow is the most important to understand the left ventricular function. In this study, we proposed a fluid-structure interaction (FSI) approach to simulate the blood flow in patient-specific model by combining both mitral and aortic valves. To accommodate the large mesh deformation, moving arbitrary Lagrangian-Eulerian (ALE) meshes were used for moving ventricular wall and rotating leaflets of valves. The left ventricular wall was predescribed according to the points acquired from magnetic resonance image (MRI). Mitral and aortic valves were integrated into the model by assuming each leaflet as a rigid body. Fluid-structure interaction (FSI) approach was adopted to capture the rapid motion of leaflets. The simulation results were qualitatively similar to the measurements reported in literatures. To the best of our knowledge, this is the first to simulate the patient-specific ventricular flow with the presence of both mitral and aortic valves.
研究心室内血流对于理解左心室功能最为重要。在本研究中，我们提出了一种流固耦合（FSI）方法，通过结合二尖瓣和主动脉瓣来模拟特定患者模型中的血流。为了适应大网格变形，采用移动任意拉格朗日 - 欧拉（ALE）网格来模拟心室壁的运动和瓣膜小叶的旋转。左心室壁根据从磁共振图像（MRI）获取的点预先描述。通过将每个小叶视为刚体，将二尖瓣和主动脉瓣整合到模型中。采用流固耦合（FSI）方法来捕捉小叶的快速运动。模拟结果在定性上与文献报道的测量结果相似。据我们所知，这是首次在同时存在二尖瓣和主动脉瓣的情况下模拟特定患者的心室内血流。
