Biofluid Mechanics Research Laboratory, 2 Engineering Drive 3, Department of Bioengineering, National University of Singapore, 117576 Singapore, Singapore; Cardiac Mechanics Engineering and Physiology Unit, National Heart Centre Singapore, Mistri Wing 17, 3rd Hospital Avenue, 168752 Singapore, Singapore.
Cardiac Mechanics Engineering and Physiology Unit, National Heart Centre Singapore, Mistri Wing 17, 3rd Hospital Avenue, 168752 Singapore, Singapore; Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore, Singapore.
Comput Methods Programs Biomed. 2014 Feb;113(2):474-82. doi: 10.1016/j.cmpb.2013.11.009. Epub 2013 Nov 27.
Intraventricular flow is important in understanding left ventricular function; however, relevant numerical simulations are limited, especially when heart valve function is taken into account. In this study, intraventricular flow in a patient-specific left ventricle has been modelled in two-dimension (2D) with both mitral and aortic valves integrated. The arbitrary Lagrangian-Eulerian (ALE) approach was employed to handle the large mesh deformation induced by the beating ventricular wall and moving leaflets. Ventricular wall deformation was predefined based on MRI data, while leaflet dynamics were predicted numerically by fluid-structure interaction (FSI). Comparisons of simulation results with in vitro and in vivo measurements reported in the literature demonstrated that numerical method in combination with MRI was able to predict qualitatively the patient-specific intraventricular flow. To the best of our knowledge, we are the first to simulate patient-specific ventricular flow taking into account both mitral and aortic valves.
心室腔内流动对于理解左心室功能非常重要；然而，相关的数值模拟是有限的，尤其是当考虑到心脏瓣膜功能时。在这项研究中，采用二维（2D）模型模拟了特定患者的左心室腔内流动，同时整合了二尖瓣和主动脉瓣。任意拉格朗日-欧拉（ALE）方法用于处理由跳动的心室壁和移动的瓣叶引起的大网格变形。心室壁变形是根据 MRI 数据预先定义的，而瓣叶动力学则通过流固耦合（FSI）数值预测。模拟结果与文献中报道的体外和体内测量结果的比较表明，数值方法结合 MRI 能够定性地预测特定患者的心室腔内流动。据我们所知，我们是第一个考虑二尖瓣和主动脉瓣的情况下模拟特定患者心室流动的。
