Laure F, Zagury D, Saimot A G, Gallo R C, Hahn B H, Brechot C
Science. 1985 Aug 9;229(4713):561-3. doi: 10.1126/science.2410981.
A lymphotropic virus HTLV-III/LAV was recently identified as the etiologic agent of the acquired immune deficiency syndrome (AIDS). In a study of concomitant hepatitis B infections in patients with AIDS or the AIDS-related complex, DNA sequences of hepatitis B virus (HBV) were found in fresh and cultured lymphocytes from patients with AIDS even in the absence of conventional HBV serological markers. Furthermore, the restriction DNA pattern was consistent with the integration of the viral DNA. These results should prompt additional studies to reevaluate a possible role of HBV as a cofactor in AIDS in addition to the HTLV-III/LAV causal agent.
一种嗜淋巴细胞病毒HTLV-III/LAV最近被确定为获得性免疫缺陷综合征（艾滋病）的病原体。在一项对艾滋病患者或艾滋病相关综合征患者合并乙型肝炎感染的研究中，即使在没有传统乙型肝炎病毒血清学标志物的情况下，也在艾滋病患者的新鲜淋巴细胞和培养淋巴细胞中发现了乙型肝炎病毒（HBV）的DNA序列。此外，限制性DNA图谱与病毒DNA的整合一致。这些结果应促使进行更多研究，以重新评估HBV作为除HTLV-III/LAV病原体之外的艾滋病辅助因子的可能作用。
