Beumer H M, Ritter W
Respiration. 1975;32(5):363-7. doi: 10.1159/000193666.
In 4 X 10 young white male histamine-sensitive asthmatics without bronchitis or emphysema, the antagonism of fenoterol (40 mug) to bunitrolol (2.5 and 5 mg) or practolol (20 and 30 mg) was tested in an open comparative trial. Pulse frequency and several physiological parameters were determined before and after histamine challenge test, after injection of beta-blocking drug and after injection of fenotrolol. All groups were found to be equally sensitive to histamine. Bunitrolol and practolol were found to have no influence on histamine effect. It was also found that bunitrolol in the dosages tested is a much more potent beta-blocking drug in the bronchi compared to practolol in the dosages tested were equivalent. beta-Blockade of practolol (20 or 30 mg) could completely be antagonized by 40 mug fenoterol; this dosage was not sufficient to antagonize 2.5 or 5 mg bunitrolol.
在40名无支气管炎或肺气肿的年轻男性组胺敏感性哮喘患者中，进行了一项开放对比试验，测试了非诺特罗（40微克）对布尼洛尔（2.5毫克和5毫克）或普拉洛尔（20毫克和30毫克）的拮抗作用。在组胺激发试验前、注射β受体阻滞剂后以及注射非诺特罗后，测定脉搏频率和几个生理参数。发现所有组对组胺的敏感性相同。发现布尼洛尔和普拉洛尔对组胺效应无影响。还发现，在所测试的剂量下，布尼洛尔在支气管中是一种比普拉洛尔更有效的β受体阻滞剂，所测试的剂量相当。普拉洛尔（20毫克或30毫克）的β受体阻滞作用可被40微克非诺特罗完全拮抗；该剂量不足以拮抗2.5毫克或5毫克布尼洛尔。
