纤连蛋白在硬皮病（系统性硬化症）患者甲襞活检组织中的分布。

Fibronectin distribution in nailfold biopsies of scleroderma (systemic sclerosis) patients.

作者信息

Chen Z Y, Maricq H R, Pilia P A, Dobson R L, Silver R M, Ainsworth S K

出版信息

Acta Derm Venereol. 1985;65(3):185-9.

Abstract

The distribution of fibronectin (FN) was studied in skin biopsies of 13 patients with scleroderma (SD), 7 patients with dermatomyositis (D), and 10 normal controls (NC) by direct immunofluorescence. In normal tissues, continuous or segmental linear staining of the dermal-epidermal junction (DEJ) was seen. Papillary, subpapillary dermis, and papillary capillary loops showed a reticular pattern of deposition with fibronectin. Scleroderma patients revealed similar staining in the dermis and DEJ. The reticular distribution of FN appeared to stain more intensely in the dermis than in controls, especially in deeper layers. The amount of FN in walls of blood vessels from SD patients was markedly increased; all dermal vessels stained with FN and revealed considerably thicker walls and larger lumens. FN distribution in DM patients was similar to that seen in SD with an increased amount of FN staining in capillary walls.

摘要

通过直接免疫荧光法，对13例硬皮病（SD）患者、7例皮肌炎（D）患者和10例正常对照者（NC）的皮肤活检组织中纤连蛋白（FN）的分布进行了研究。在正常组织中，可见真皮 - 表皮交界处（DEJ）呈连续或节段性线性染色。乳头层、乳头下真皮和乳头毛细血管袢显示出纤连蛋白的网状沉积模式。硬皮病患者在真皮和DEJ处表现出类似的染色。FN的网状分布在真皮中似乎比对照组染色更强烈，尤其是在深层。SD患者血管壁中的FN量明显增加；所有真皮血管均被FN染色，显示出明显更厚的壁和更大的管腔。DM患者的FN分布与SD患者相似，毛细血管壁中FN染色量增加。