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用于离心微流控和大肠杆菌灭菌的无线可寻址加热器阵列

Wirelessly addressable heater array for centrifugal microfluidics and Escherichia coli sterilization.

作者信息

Chen Xing, Song Lele, Assadsangabi Babak, Fang Jie, Mohamed Ali Mohamed Sultan, Takahata Kenichi

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:5505-8. doi: 10.1109/EMBC.2013.6610796.

Abstract

Localized temperature control and heater interface remain challenges in centrifugal microfluidics and integrated lab-on-a-chip devices. This paper presents a new wireless heating method that enables selective activation of micropatterned resonant heaters using external radiofrequency (RF) fields and its applications. The wireless heaters in an array are individually activated by modulating the frequency of the external field. Temperature of 93 °C is achieved in the heater when resonated with a 0.49-W RF output power. The wireless method is demonstrated to be fully effective for heating samples under spinning at high speeds, showing its applicability to centrifugal systems. Selective sterilization of Escherichia coli through the wireless heating is also demonstrated. Healthcare applications with a focus on wound sterilization are discussed along with preliminary experiments, showing promising results.

摘要

在离心微流控和集成芯片实验室设备中,局部温度控制和加热器接口仍然是挑战。本文提出了一种新的无线加热方法,该方法能够利用外部射频(RF)场选择性激活微图案化谐振加热器及其应用。通过调制外部场的频率,可单独激活阵列中的无线加热器。当与0.49瓦的射频输出功率共振时,加热器的温度可达93°C。实验证明,该无线方法在高速旋转时对样品加热完全有效,显示了其在离心系统中的适用性。还展示了通过无线加热对大肠杆菌进行选择性杀菌。文中讨论了以伤口杀菌为重点的医疗保健应用以及初步实验,结果很有前景。

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