University of California, Irvine, Irvine, CA 92697, USA.
Lab Chip. 2010 Jul 21;10(14):1758-73. doi: 10.1039/b924109d. Epub 2010 May 28.
The centrifugal microfluidic platform has been a focus of academic and industrial research efforts for almost 40 years. Primarily targeting biomedical applications, a range of assays have been adapted on the system; however, the platform has found limited commercial success as a research or clinical tool. Nonetheless, new developments in centrifugal microfluidic technologies have the potential to establish wide-spread utilization of the platform. This paper presents an in-depth review of the centrifugal microfluidic platform, while highlighting recent progress in the field and outlining the potential for future applications. An overview of centrifugal microfluidic technologies is presented, including descriptions of advantages of the platform as a microfluidic handling system and the principles behind centrifugal fluidic manipulation. The paper also discusses a history of significant centrifugal microfluidic platform developments with an explanation of the evolution of the platform as it pertains to academia and industry. Lastly, we review the few centrifugal microfluidic-based sample-to-answer analysis systems shown to date and examine the challenges to be tackled before the centrifugal platform can be more broadly accepted as a new diagnostic platform. In particular, fully integrated, easy to operate, inexpensive and accurate microfluidic tools in the area of in vitro nucleic acid diagnostics are discussed.
离心微流控平台已经成为学术和工业研究的焦点近 40 年。主要针对生物医学应用，该系统已经适应了一系列的检测方法;然而，该平台作为研究或临床工具的商业成功有限。尽管如此，离心微流控技术的新发展有可能广泛应用该平台。本文对离心微流控平台进行了深入的回顾，同时强调了该领域的最新进展，并概述了未来应用的潜力。介绍了离心微流控技术的概述，包括该平台作为微流控处理系统的优点描述和离心流控操作背后的原理。本文还讨论了一些具有重要意义的离心微流控平台的发展历史，并解释了该平台在学术界和工业界的发展演变。最后，我们回顾了迄今为止已经展示的少数基于离心微流控的样本到答案分析系统，并研究了在离心平台能够更广泛地被接受为新的诊断平台之前需要解决的挑战。特别是，讨论了体外核酸诊断领域中完全集成、易于操作、价格低廉且准确的微流控工具。
