Balakliets N I, Tsyganenko A Ia
Antibiot Med Biotekhnol. 1985 May;30(5):364-9.
The effect of benzylpenicillin and tetracycline on phagocytosis by leukocytes of abdominal cavity exudate, activity of lysozyme and beta-lysines in the blood serum, content of nucleic acids and activity of succinate dehydrogenase and phosphatase (total and acid) in the liver cells was studied on albino mice infected by staphylococci. It was shown that the treatment of the animals with benzylpenicillin and tetracycline for 5 days affected the cellular and nonspecific humoral defence and activity of succinate dehydrogenase and phosphatase. A decrease in the indices of the phagocytosis, activity of lysozyme, beta-lysines, succinate dehydrogenase and phosphatase was observed. Tetracycline had a more pronounced inhibitory effect. Neither benzylpenicillin, nor tetracycline had an effect on the content of nucleic acids in liver cells.
研究了苄青霉素和四环素对感染葡萄球菌的白化小鼠腹腔渗出液白细胞吞噬作用、血清中溶菌酶和β-赖氨酸活性、肝细胞中核酸含量以及琥珀酸脱氢酶和磷酸酶（总酶和酸性酶）活性的影响。结果表明，用苄青霉素和四环素对动物进行5天治疗影响了细胞和非特异性体液防御以及琥珀酸脱氢酶和磷酸酶的活性。观察到吞噬作用指标、溶菌酶、β-赖氨酸、琥珀酸脱氢酶和磷酸酶活性下降。四环素的抑制作用更明显。苄青霉素和四环素均对肝细胞中的核酸含量没有影响。
