Balakliets N I, Tsyganenko A Ia
Antibiotiki. 1984 May;29(5):350-3.
The effect of benzylpenicillin and tetracycline on the activity, intensity and completion of phagocytosis with the leucocytes of the peritoneal exudate, on the activity of lysozyme and beta-lysins of the blood serum, on the content of nucleic acids, the activity of succinate dehydrogenase and total and acid phosphatase in the liver and kidney cells was studied experimentally on noninfected albino mice. The study showed that administration of benzylpenicillin and tetracycline to the animals for 5 days induced a decrease in the activity of the cell and humoral defence and the activity of the above enzymes in the liver and kidney cells. The content of the nucleic acids did not change under the effect of the antibiotics.
在未感染的白化小鼠身上进行了实验研究，观察苄青霉素和四环素对腹膜渗出液白细胞吞噬作用的活性、强度及完成情况、血清溶菌酶和β-溶素的活性、肝脏和肾脏细胞中核酸含量、琥珀酸脱氢酶以及总磷酸酶和酸性磷酸酶活性的影响。研究表明，给动物连续5天施用苄青霉素和四环素会导致细胞和体液防御活性以及肝脏和肾脏细胞中上述酶的活性降低。在抗生素作用下，核酸含量没有变化。
