Kamisli Suat, Ciftci Osman, Cetin Asli, Kaya Kursat, Kamisli Ozden, Celik Hamit
Nutr Neurosci. 2014 Apr;17(3):116-26. doi: 10.1179/1476830513Y.0000000074. Epub 2013 Nov 26.
The protective effects of fish oil (FO) on cisplatin (CP)-induced central and peripheral neurotoxicity were investigated in rats.
Rats (n = 28) were divided equally into four groups, the first group was kept as a control. In the second and third groups, CP and FO were given at doses of 7 mg/kg and 1 softgel/rat/day, respectively. In the fourth group, CP and FO were given together at the same doses.
Although CP caused significant oxidative damage, via induction of lipid peroxidation and reduction in the antioxidant defense system potency, FO treatment largely reversed these effects. CP also resulted in histopathological damage, such as apoptosis, and electromyographical changes in the sciatic nerve. FO treatment partially prevented the histopathological and electromyographical effects of CP.
CP has severe central and peripheral neurotoxic effects in rats and these effects were largely prevented by FO treatment. Thus, it appears that co-administration of FO with CP may be a useful approach to attenuate the negative effects of CP on the nervous system.
研究鱼油（FO）对顺铂（CP）诱导的大鼠中枢和外周神经毒性的保护作用。
将28只大鼠平均分为四组，第一组作为对照组。第二组和第三组分别给予剂量为7mg/kg的CP和1粒软胶囊/大鼠/天的FO。第四组同时给予相同剂量的CP和FO。
尽管CP通过诱导脂质过氧化和降低抗氧化防御系统效能引起显著的氧化损伤，但FO治疗在很大程度上逆转了这些效应。CP还导致组织病理学损伤，如凋亡，以及坐骨神经的肌电图变化。FO治疗部分预防了CP的组织病理学和肌电图效应。
CP在大鼠中具有严重的中枢和外周神经毒性作用，而FO治疗在很大程度上预防了这些作用。因此，CP与FO联合给药似乎可能是减轻CP对神经系统负面影响的一种有用方法。
