Sanchez Mi, Hu S, Miteva M, Tosti A
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
J Eur Acad Dermatol Venereol. 2014 Nov;28(11):1560-2. doi: 10.1111/jdv.12269. Epub 2013 Sep 24.
Onychomatricoma is a benign fibroepithelial nail matrix tumor that infiltrates the nail plate leading to multiple tunneled cavities lined with matrix epithelium and filled with serum. Diagnostic features of onychomatricoma on reflectance confocal microscopy (RCM) have not been previously described.
We sought to demonstrate the feasibility of using RCM to diagnose onychomatricoma.
Reflectance confocal microscopy was used to evaluate four patients with onychomatricoma before tumor excision. We evaluated the affected nail and one unaffected nail of each patient with VivaScope 1500 (Lucid Inc., Rochester, NY, USA).
Reflectance confocal microscopy evaluation of onychomatricomas revealed longitudinal dark areas and bright/grey lines, forming channel like structures. The channels were outlined by bright circular lines with grey dot centers. These RCM features correlated with the pathology of the onychomatricomas within the nail plate.
Proximal portion of onychomatricoma was not reach by RCM.
Reflectance confocal microscopy can assist in rapid and noninvasive diagnosis of onychomatricoma showing characteristic channel like structures within nail plates.
甲母质瘤是一种良性纤维上皮性甲母质肿瘤，可浸润甲板，导致多个由甲母质上皮衬里并充满血清的隧道状腔隙。反射式共聚焦显微镜（RCM）下甲母质瘤的诊断特征此前尚未见报道。
我们试图证明使用RCM诊断甲母质瘤的可行性。
在肿瘤切除前，使用反射式共聚焦显微镜对4例甲母质瘤患者进行评估。我们使用VivaScope 1500（美国纽约罗切斯特市的Lucid公司）对每位患者的患甲和1个未受影响的指甲进行评估。
甲母质瘤的反射式共聚焦显微镜评估显示有纵向暗区和亮/灰线，形成类似通道的结构。这些通道由中心为灰点的亮环线勾勒。这些RCM特征与甲板内甲母质瘤的病理学表现相关。
RCM无法观察到甲母质瘤的近端部分。
反射式共聚焦显微镜有助于对甲母质瘤进行快速、无创诊断，其在甲板内显示出特征性的类似通道的结构。
