Nubile G, Saccone A, Di Gregorio M, Rossi M, Tresca E
Boll Soc Ital Biol Sper. 1985 Mar 30;61(3):357-63.
The authors tested the influence of gentamicin, spectinomycin dihydrostreptomycin on the ADP and epinephrine in vitro induced platelet aggregation. Our aim was to demonstrate if platelet aggregation in vitro had some influences by antibiotics. A reduction in platelet aggregability, strictly dependent from the used antibiotic dose was observed. We have studied platelet function thanks to Born's method, adding to PRP gradual therapeutics doses of antibiotics. The results showed a reduction of platelet function which was dose-depended, and, particularly, gentamicin seemed to be the most effective among aminoglycosides. An interference between these drugs and the ADP and epinephrine binding to specific platelet receptor sites is proposed.
作者测试了庆大霉素、壮观霉素二氢链霉素对体外诱导的ADP和肾上腺素所致血小板聚集的影响。我们的目的是证明抗生素是否对体外血小板聚集有影响。观察到血小板聚集性降低，这严格取决于所用抗生素的剂量。我们借助博恩氏法研究血小板功能，向富血小板血浆（PRP）中逐渐添加治疗剂量的抗生素。结果显示血小板功能降低呈剂量依赖性，特别是，庆大霉素似乎是氨基糖苷类中最有效的。有人提出这些药物与ADP和肾上腺素与特定血小板受体位点的结合之间存在干扰。
