Cronberg S, Wallmark E, Söderberg I
Folia Haematol Int Mag Klin Morphol Blutforsch. 1984;111(6):725-34.
The influence of ten betalactam antibiotics and ten other antibiotics on platelet aggregation induced by ADP or adrenaline was investigated in vitro. In concentrations of 900 mg/l most antimicrobial drugs exerted a moderate inhibition that was not seen in concentrations of 90 mg/l that better corresponded to therapeutic levels. The influence on the platelets of a single large intravenous dose was also tested using eight antimicrobial drugs, viz. benzylpenicillin, ampicillin, carbenicillin, piperacillin, cloxacillin, cefuroxime, cefotaxime and erythromycin. Each drug was given to five healthy volunteers but none caused any significant inhibition of platelet aggregation. The second wave of aggregation persisted after administration of the drugs and it was even seen after the administration of such a high dose as 10 g of carbenicillin.
体外研究了10种β-内酰胺类抗生素和10种其他抗生素对ADP或肾上腺素诱导的血小板聚集的影响。在900mg/L的浓度下，大多数抗菌药物产生中度抑制作用，而在90mg/L的浓度下则未观察到这种抑制作用，90mg/L的浓度更符合治疗水平。还使用8种抗菌药物，即苄青霉素、氨苄青霉素、羧苄青霉素、哌拉西林、氯唑西林、头孢呋辛、头孢噻肟和红霉素，测试了单次大剂量静脉给药对血小板的影响。每种药物给予5名健康志愿者，但均未引起血小板聚集的任何显著抑制。给药后聚集的第二波持续存在，甚至在给予10g羧苄青霉素这样的高剂量后也能观察到。
